Why we called Resveratrol is the greatest discovery since Antibiotics (part 1)
Resveratrol
is a poly-phenolic compound with new research studies almost appearing
daily. Experts already claim it can help you beat cancer - from
brain tumours to breast, colon, prostate cancers and many more. It is also
claimed to help in Dementia and Alzheimer´s, heart disease and even weight
loss (what is Reserveratrol? Click here for more)
Anti-cancer benefits
In 2008 when a new study was published,
involving a major collaborative exercise on human consumption, between Rafael
de Cabo, Ph.D. at the National Institute on Aging (NIA), David A. Sinclair,
Ph.D. at Harvard Medical School and 13 other worldwide institutions (Cell
Metabolism; July 3rd 2008). They confirmed its many health benefits.
Memorial Sloan-Kettering, the American pillar
of cancer treatment, conducted research on the inflammatory effects on cells
leading to cancer. It is widely known that an enzyme COX-2, lies behind the stimulation of localised hormones
(eicosanoids) causing inflammation, the precursor to cancer. In the
research Resveratrol completely
turned off the COX-2 driver. MD Anderson´s studies have shown this
same anti-inflammatory benefit too. Plus, after conversion in the liver to a
sulphated form the compound can attack several of the steps in the
cancer process even killing cancer cells.
The excitement continued when it was found
how resveratrol worked directly as an anti-cancer compound:
Resveratrol has been shown to be attacked by an enzyme unique to pre-cancerous
and cancer cells - the cytochrome P450 enzyme, CYP 1B1. The converted compound
is a toxic substance (piceatannol) which brings about cell death.
Resveratrol has been dubbed a pro-drug as a consequence (Br J Cancer, 2002;
86: 774-778). Much work has been added to this by Professors Potter and
Burke in the UK as they look into Salvestrols - natural compounds in
certain foods that can stop the development of cancer.
Over the last decade there have been a number
of studies on resveratrol and its
abilities to stop the re-growth of cancer stem cells. These cells
may well lie at the core of most tumours and there is currently no
chermotherapy that can deal with them. However National Cancer Institute
researchers showed certain bioactive natural compounds could stop their
re-growth.
According to Pandy PR et al (Breast Cancer
Res Treat. 2011 Nov 30 (2) 387-98) resveratrol
has an anti-tumour effect with various types of cancer, being able
to induce cancer cell death (apoptosis) in the cancer stem-like cells through
altering the cells´ death coding.
Several studies have confirmed that
cancer stem cells can proliferate and self-renew extensively due to their
ability to generate anti-cell death and even drug-resistant proteins. Research
by Shankar S. Nall D, Tang S-N, Meeker D, Passarini J et all (2011) showed resveratrol
inhibits human pancreatic stem cells and concluded resveratrol could be used in the management of
pancreatic cancer.
According to the American Association of
Cancer Research, resveratrol may be an important agent for prostate
cancer treatment (Dept of Urology and Biochemistry, Mayo Clinic, 1999).
Resveratrol inhibits androgen action and represses certain androgen genes., so
it inhibits androgen-stimulated cell growth and gene expression.
There were other studies showing that resveratrol
could work with the immune system to
inhibit blood supply to prostate tumours ( Greehey Children´s Cancer
Research Institute, San Antonio, Texas)
And for
breast cancer too - the
New York Medical Collegein Valhalla) published research in 2011 showing
resveratrol, and a metabolite triacetyl-resveratrol, can inhibit breast
cancer, whether oestrogen positive or negative (International Journal of
Cancer Jan 2011)
Several studies show that resveratrol’s
action seems to be dose and duration dependent. At low doses it may encourage
adult stem cells and cancer stem cells to re-grow but at higher doses,
resveratrol inhibits cancer stem cell renewal.
A combination of red grape polyphenols at
relatively low doses can be effective at preventing breast cancer from
progressing to become an advanced disease, according to a study by S. F.
Dharmawardhane of Universidad Central del Caribe School of Medicine in Bayamon,
Puerto Rico (pub.Translational Oncology). The research then looked at
the use of these polyphenols and showed they enhanced drug action against breast
cancer: RQC (resveratrol, quercetin and catechin) treatment inhibits breast
cancer progression and may potentiate anti-EGFR therapy by inhibition of
Akt/mTOR signaling. The research even recommended supplementation.
According to various M D Anderson studies, Resveratrol improves chemotherapy success and reduces side-effects; it also increases
glutathione levels
which help oxygenate and restore healthy cells. (Oxygen kills cancer cells).
The action in improving chemotherapy, has
been repeated with Radiotherapy at the University of Missouri. Resveratrol has
been shown also to increase levels of
two naturally occuring anti-cancer proteins (perforin and granzyme B)
throughout the body, aiding the body´s fight against any cancer but
particularly prostate cancer.
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